I was at the Wizard World Chicago comic book convention yesterday and was talking with the friends I was with about drawing comics 100% digitally. Just for fun, I threw together this Hulk sketch today start to finish in Photoshop. The inking is not as smooth as real brush work, but I think with some practice and modifications to my style it can work. The hardest part was sketching in the initial layout. There's something about looking at a drawing on paper that gives you a better perspective on design and proportion that you lose going digital (for me anyway).
It definitely went a lot faster than doing it traditionally, but I don't know if the drop in quality offsets that: